Kongkai Zhu Selected Research

Methyltransferases

2/2019	Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.
3/2016	Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.
10/2015	Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.
11/2014	Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Kongkai Zhu Research Topics

Disease

13	Neoplasms (Cancer) 01/2022 - 01/2013
4	Carcinogenesis 01/2019 - 02/2014
3	Lymphoma (Lymphomas) 02/2019 - 11/2014
2	Leukemia 02/2019 - 03/2016
1	Thrombosis (Thrombus) 01/2022
1	Hemorrhage 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Pathologic Processes 10/2020
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2019
1	Glioblastoma (Glioblastoma Multiforme) 12/2018
1	Cardiomyopathies (Cardiomyopathy) 12/2018
1	Alzheimer Disease (Alzheimer's Disease) 08/2018
1	Hepatocellular Carcinoma (Hepatoma) 08/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Alopecia Areata 10/2015
1	Vascular Diseases (Vascular Disease) 10/2015
1	Infections 09/2014
1	Clostridium Infections 09/2014
1	medullary Thyroid cancer 02/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2013

Drug/Important Bio-Agent (IBA)

7	Pharmaceutical PreparationsIBA 01/2021 - 01/2013
5	EnzymesIBA 12/2018 - 01/2013
4	MethyltransferasesIBA 02/2019 - 11/2014
4	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2019 - 01/2013
3	Arginine (L-Arginine)FDA Link 02/2019 - 01/2013
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2019
2	Polycomb Repressive Complex 2IBA 01/2020 - 11/2014
2	Biological ProductsIBA 01/2019 - 10/2015
2	Histones (Histone)IBA 03/2016 - 02/2014
2	Histone MethyltransferasesIBA 03/2016 - 10/2015
2	Lysine (L-Lysine)FDA Link 03/2016 - 10/2015
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022
1	CarbohydratesIBA 01/2021
1	BenzopyransIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Glycoside Hydrolases (Endoglycosidases)IBA 01/2021
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2021
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 10/2020
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 09/2020
1	Histone Deacetylase InhibitorsIBA 07/2019
1	coumarinIBA 07/2019
1	AlkaloidsIBA 01/2019
1	LipopolysaccharidesIBA 12/2018
1	Nuclear Proteins (Protein, Nuclear)IBA 12/2018
1	CytokinesIBA 12/2018
1	Donepezil (Aricept)FDA LinkGeneric 08/2018
1	Tacrine (Cognex)FDA Link 08/2018
1	ArsenicIBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	ErbB Receptors (EGF Receptor)IBA 01/2018
1	Gefitinib (Iressa)FDA Link 01/2018
1	AstemizoleIBA 11/2014
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2014
1	Transcription Factors (Transcription Factor)IBA 02/2014
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 02/2014
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2014
1	cabozantinibIBA 02/2014

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 01/2022 - 07/2019
2	Therapeutics 11/2014 - 02/2014
1	Photochemotherapy (Photodynamic Therapy) 09/2020
1	Intraperitoneal Injections 12/2018